Added: Chitara Vaughan - Date: 07.01.2022 18:42 - Views: 49446 - Clicks: 1411
Spondylarthritis SpA represents a group of arthritidies that share clinical features such as inflammatory back pain and inflammation at sites where tendons attach to bone. It includes ankylosing spondylitis ASpsoriatic arthritis, inflammatory bowel-disease-related arthritis, reactive arthritis ReA and undifferentiated spondylarthritides uSpA. Since Chlamydia trachomatis or Chlamydia pneumoniae which are often asymptomatic frequently cause ReA, a new study examined whether there was a connection between these two infections and uSpA.
Led by John D. Carter of theUniversity of South Florida, the study involved blood and synovial tissue analysis from 26 patients who had chronic uSpA or Chlamydia -induced ReA. Synovial tissue samples from osteoarthritis patients were used as controls. Samples were analyzed to assess chlamydial DNA and the 26 subjects were asked if they had any known exposure to Chlamydia trachomatis or Chlamydia pneumoniae and if so, the infection was documented in relation to the onset of their uSpA. They also underwent a physical exam that included evaluation of swollen and tender ts and other symptoms of SpA.
The showed that the rate of Chlamydia infection was 62 percent in uSpA patients, ificantly higher than the 12 percent seen in control subjects.
It is believed that as many ascases of Chlamydia trachomatis -induced ReA may appear in the U. This is a low estimate since it does not include cases resulting from Chlamydia pneumoniae. Most women with genital Chlamydia trachomatis infection have no symptoms at the time of the initial infection; this was also true of the patients in the study who had DNA evidence of Chlamydia. For Chlamydia pneumoniaeas many as 70 percent of acute infections are asymptomatic and, even when there are symptoms, definitive identification of the organism is rare.
The authors point out that relying on identification of a symptomatic infection may therefore result in routine underdiagnosis or misdiagnosis of Chlamydia -induced ReA. They conclude that although there is no diagnostic test for Chlamydia -induced ReA, testing for chlamydial DNA in the synovial tissue of patients thought to have ReA may be the most accurate way of diagnosing the condition. Espinoza, Louis R. Vasey, Alan P. You've successfully added to your alerts.
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Chlamydia May Play Role In a Type of Arthritis